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www.osai.com/FAQ/Port25.asp
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The most common problem in sending mail is that your ISP has port 25 blocked going out of their network. They do this to prevent spammers from connecting directly to external webservers and delivering Junk Email. If you have a problem sending mail, but are able to receive mail just fine, then check your SMTP Settings and change the port number to 2500 or 2525.
From Microsoft Outlook...
You should now be able to connect to your SMTP Servers on the new port, 2525